The Research
We study the cellular intersections of protein modification, lysosomal degradation, and cellular metabolism.
We are using chemical and cell biological approaches to understand fundamental cell biology, define the basis for human disease, and target the undruggable proteome with proximity-based medicine.
Projects
Mapping Arginine Methylation
We are using innovative chemical biology tools to study how cells use arginine methylation to mark certain proteins for degradation.
Chemical tools for induced proximity
With our recently developed chemical platform, MrTAC, we can force cells to degrade disease-causing proteins in lysosomes.
Cancer Cell Metabolism
Using cell and biochemical approaches, we study how cancer cells hijack lysosomal activity to enable unrestricted cell growth and expansion.
Organ Crosstalk
We aim to understand how byproducts of arginine methylation drive crosstalk between organs like the bone & kidney.
Molecular Mechanisms of Proteostasis
Using CRISPR screening and cell biology techniques, we are investigating the mechanisms for how cells use arginine methylation to regulate protein synthesis and degradation.
Learn more!
Albrecht Laboratory 