Protein homeostasis is essential for all living cells and organisms.
We study a new degradation tag, Arginine methylation, which signals proteins for lysosomal degradation.
Proteins are methylated by Protein Arginine Methyltransferase 1 (PRMT1) and produce metabolites that enable crosstalk between organs such as the bone and kidney.
Cancer Cell Metabolism
Cancer cells hijack lysosomal activity to replenish nutrients that enable unrestricted growth and expansion.
Arginine methylation drives genetic disease.
Loss of a single methylated residue led to sudden cardiac death in a patient with Arrhythmogenic Cardiomyopathy.
Lauren’s image featured on the cover of JCB, 2015.